Point Mutation in the Group B Streptococcal pbp2x Gene Conferring Decreased Susceptibility to -Lactam Antibiotics
نویسندگان
چکیده
Point Mutation in the Group B Streptococcal pbp2x Gene Conferring Decreased Susceptibility to -Lactam Antibiotics Samira Dahesh,† Mary E. Hensler,† Nina M. Van Sorge, Robert E. Gertz, Jr., Stephanie Schrag, Victor Nizet, and Bernard W. Beall* Division of Pharmacology and Drug Discovery, Department of Pediatrics, and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, and Respiratory Diseases Branch, Division of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia
منابع مشابه
Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics.
Beta-lactam antibiotics (BLAs) are the first-line agents used against group B streptococci (GBS) infection. A clonal set of four independent, invasive GBS isolates with elevated MICs to BLAs were identified that shared a pbp2x mutation (Q557E) corresponding to a resistance-conferring pneumococcal mutation. BLA sensitivity was restored through allelic replacement or complementation with the wild...
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